Drug screening using model systems: some basics

Drug screening using model systems: some basics

An increasing number of laboratories that focus on model systems are considering drug screening. Executing a drug screen is complicated enough. But the path for moving initial hits towards the clinic requires a different knowledge base and even a different mindset. In this Editorial I discuss the importance of doing some homework before you start screening. 'Lead hits', 'patentable chemical spa...

Some Basics In Modeling Of Mechatronic Systems

Some Basics on Tolerances

In this paper we deal with sensitivity analysis of combinatorial optimization problems and its fundamental term, the tolerance. For three classes of objective functions (Σ,Π,MAX) we give some basic properties on upper and lower tolerances. We show that the upper tolerance of an element is well defined, how to compute the upper tolerance of an element, and give equivalent formulations when the u...

Basics of Model Checking

1 Logical Specifications 3 1.1 System Behaviours . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.1.1 Time Flows . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.1.2 Linear Time Behaviours . . . . . . . . . . . . . . . . . . . . 4 1.1.3 Branching Time Behaviours . . . . . . . . . . . . . . . . . . 4 1.1.4 The Model-Checking Problem(s) . . . . . . . . . . . . . . . 5 1.2 First-...

Microfluidic Devices for Drug Delivery Systems and Drug Screening

Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow rates of multiphase fluids, microfluidic technology enables the generation of highly stable, uniform, mo...